What Is an Aging-Related Disease? An Epidemiological Perspective.

ABSTRACT: There are no established or standardized definitions of aging-related disease. Data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were used to model the relationship between age and incidence of diseases. Clustering analysis identified 4 groups of noncommunicable diseases: Group A diseases with an exponential increase in incidence with age; Group B diseases with an exponential increase in incidence that usually peaked in late life which then declined or plateaued at the oldest ages; and Groups C and D diseases with an onset in earlier life and where incidence was stable or decreased in old age. From an epidemiological perspective, Group A diseases are "aging-related diseases" because there is an exponential association between age and incidence, and the slope of

SUBMITTER: Le Couteur DG 

PROVIDER: S-EPMC9678203 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature