Interneurons of fan-shaped body promote arousal in Drosophila.

ABSTRACT: Sleep is required to maintain physiological functions and is widely conserved across species. To understand the sleep-regulatory mechanisms, sleep-regulating genes and neuronal circuits are studied in various animal species. In the sleep-regulatory neuronal circuits in Drosophila melanogaster, the dorsal fan-shaped body (dFB) is a major sleep-promoting region. However, other sleep-regulating neuronal circuits were not well identified. We recently found that arousal-promoting T1 dopamine neurons, interneurons of protocerebral bridge (PB) neurons, and PB neurons innervating the ventral part of the FB form a sleep-regulatory circuit, which we named "the PB-FB pathway". In the exploration of other sleep-regulatory circuits, we found that activation of FB interneurons, also known as pontine neu

SUBMITTER: Kato YS 

PROVIDER: S-EPMC9678257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature