Abnormal platelet immunophenotypes and percentage of giant platelets in myelodysplastic syndrome: A pilot study.

ABSTRACT:

Objectives

Myelodysplastic syndrome (MDS) is a heterogeneous hematopoietic stem cell disorder with thrombocytopenia. Flow cytometric immunophenotyping of blood cells has been instrumental in diagnosis as co-criteria, but the data regarding platelets remains lacking. This study aims to determine if there is a difference in surface antigen levels on platelets by comparing surface antigen levels in MDS patients and healthy control subjects. Concurrently, as flow cytometric gating can reveal the diameter of cells, this study will investigate differences in giant platelet percentage by comparing these percentages in high- and low-risk MDS patients.

Study design

Twenty newly diagnosed MDS patients were enrolled in this study. Platelet surface antigen levels were determined by meas

SUBMITTER: Wu YF 

PROVIDER: S-EPMC9678267 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature