The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy.

ABSTRACT: Proliferative Diabetic Retinopathy (PDR) is a chronic complication of Diabetes and the main cause of blindness among the world's working population at present. While there have been many studies on the pathogenesis of PDR, its intrinsic molecular mechanisms have not yet been fully elucidated. In recent years, several studies have employed bulk RNA-sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) to profile differentially expressed genes (DEGs) and cellular components associated with PDR. This study adds to this expanding body of work by identifying PDR's target genes and cellular components by conducting an integrated transcriptome bioinformatics analysis. This study integrately examined two public bulk RNA-seq datasets(including 11 PDR patients and 7 controls) and one singl

SUBMITTER: Gao N 

PROVIDER: S-EPMC9678275 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature