Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities.

ABSTRACT: Although immunotherapy research to date has focused largely on T cells, there is mounting evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour-infiltrating B lymphocytes (TIL-Bs)) have a crucial, synergistic role in tumour control. In many cancers, TIL-Bs have demonstrated strong predictive and prognostic significance in the context of both standard treatments and immune checkpoint blockade, offering the prospect of new therapeutic opportunities that leverage their unique immunological properties. Drawing insights from autoimmunity, we review the molecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulatory pathways relevant to TIL-Bs in human cancer. Although the field is young, the emerging picture is tha

SUBMITTER: Laumont CM 

PROVIDER: S-EPMC9678336 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature