The effect of different administrations of testosterone therapy on adverse prostate events: A Bayesian network meta-analysis.

ABSTRACT:

Background

Hypogonadism has become a major cause endangering men's health and quality of life all over the world. Testosterone Therapy (TT) is a widely accepted treatment for relieving hypogonadal symptoms. However, the effect of different administrations of TT on prostate safety is still unclear.

Methods

We did a thorough search of PubMed, Embase and Cochrane Library to identify eligible studies up to January 2022. Randomized controlled trials (RCTs) and Cohort studies evaluating the impacts of using different formulations of TT on prostate parameters were included. Changes of prostate-specific antigen (PSA) level and prostate cancer (Pca) cases were used as the primary outcomes. Quality of individual studies was estimated by RoB₂ (Cochrane tool for assessing the

SUBMITTER: Zeng B 

PROVIDER: S-EPMC9678341 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature