Multiomics data analysis workflow to assess severity in longitudinal plasma samples of COVID-19 patients.

ABSTRACT: Elucidation of molecular markers related to the mounted immune response is crucial for understanding the disease pathogenesis. In this article, we present the mass-spectrometry-based metabolomic and proteomic data of blood plasma of COVID-19 patients collected at two-time points, which showed a transition from non-severe to severe conditions during these time points. Metabolites were extracted and subjected to mass spectrometric analysis using the Q-Exactive mass spectrometer. For proteomic analysis, depleted plasma samples were tryptic digested and subjected to mass spectrometry analysis. The expression of a few significant proteins was also validated by employing the targeted proteomic approach of multiple reaction monitoring (MRM). Integrative pathway analysis was performed with the sig

SUBMITTER: Rajoria S 

PROVIDER: S-EPMC9678393 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature