Smooth muscle cell FTO regulates contractile function.

ABSTRACT: The fat mass and obesity gene (FTO) is a N⁶-methyladenosine RNA demethylase that was initially linked by Genome-wide association studies to increased rates of obesity. Subsequent studies have revealed multiple mass-independent effects of the gene, including cardiac myocyte contractility. We created a mouse with a conditional and inducible smooth muscle cell deletion of Fto (Myh11 Cre⁺ Fto^fl/fl) and did not observe any changes in mouse body mass or mitochondrial metabolism. However, the mice had significantly decreased blood pressure (hypotensive), despite increased heart rate and sodium, and significantly increased plasma renin. Remarkably, the third-order mesenteric arteries from these mice had almost no myogenic tone or capacity to constrict

SUBMITTER: Luse MA 

PROVIDER: S-EPMC9678421 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature