Association between microRNA-146a rs2910164 polymorphism and coronary heart disease: An updated meta-analysis.

ABSTRACT:

Background

Coronary heart disease (CHD) is one of the manifestations of atherosclerosis with a high morbidity rate. MicroRNA (miRNA)-146a rs2910164, a single nucleotide polymorphism, is associated with the progression of CHD risk. However, the results are controversial and uncertain. Therefore, an updated meta-analysis was conducted to evaluate the association between rs2910164 and CHD susceptibility.

Methods

PubMed, Cochrane Library, EMBASE, Web of Science, China's National Knowledge Infrastructure, VIP, and Wan fang were searched for the eligible articles until April 30, 2022. The odds ratios (ORs) with 95% confidence interval (CIs) were calculated to assess the correlation. Bonferroni correction was utilized between multiple comparisons. Trial sequential analysis was perf

SUBMITTER: Bao Q 

PROVIDER: S-EPMC9678560 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature