Old macrophages lose their (circadian) rhythm.

ABSTRACT: Blacher and colleagues have discovered that the circadian patterns of macrophage gene expression and immune function that exist in young mice are disrupted in aging mice. KLF4 was identified as a key transcription factor (TF) regulating rhythmic expression of immune genes, which is lost in old macrophages.

SUBMITTER: McRae HM 

PROVIDER: S-EPMC9678643 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature