Associations of body mass index, fasting insulin, and inflammation with mortality: a prospective cohort study.

ABSTRACT:

Background/objectives

Obesity is often considered to increase the risk for premature mortality. Higher fasting insulin and c-reactive protein are associated with higher body mass index (BMI) and all-cause mortality, so may confound the association between obesity and mortality. Our objective was to determine the independent associations between BMI, fasting insulin, c-reactive protein, and all-cause mortality in a general population sample.

Methods

This prospective cohort study included non-institutionalized US adults (≥20 years) from the National Health and Nutrition Examination Surveys 1999-2000 to 2013-2014. The main exposures of interest were BMI, fasting insulin, c-reactive protein. Mortality data were obtained through linking participants to the National Death Index (e

SUBMITTER: Wiebe N 

PROVIDER: S-EPMC9678791 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature