The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.

ABSTRACT: Cannabis is among the most widely consumed psychoactive substances worldwide. Individual differences in cannabis use phenotypes can partly be explained by genetic differences. Technical and methodological advances have increased our understanding of the genetic aetiology of cannabis use. This narrative review discusses the genetic literature on cannabis use, covering twin, linkage, and candidate-gene studies, and the more recent genome-wide association studies (GWASs), as well as the interplay between genetic and environmental factors. Not only do we focus on the insights that these methods have provided on the genetic aetiology of cannabis use, but also on how they have helped to clarify the relationship between cannabis use and co-occurring traits, such as the use of other substances and

SUBMITTER: Verweij KJH 

PROVIDER: S-EPMC9678872 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature