A theory-driven synthesis of symmetric and unsymmetric 1,2-bis(diphenylphosphino)ethane analogues via radical difunctionalization of ethylene.

ABSTRACT: 1,2-Bis(diphenylphosphino)ethane (DPPE) and its synthetic analogues are important structural motifs in organic synthesis, particularly as diphosphine ligands with a C₂-alkyl-linker chain. Since DPPE is known to bind to many metal centers in a bidentate fashion to stabilize the corresponding metal complex via the chelation effect originating from its entropic advantage over monodentate ligands, it is often used in transition-metal-catalyzed transformations. Symmetric DPPE derivatives (Ar¹₂P-CH₂-CH₂-PAr¹₂) are well-known and readily prepared, but electronically and sterically unsymmetric DPPE (Ar¹₂P-CH₂-CH₂-PAr²₂; Ar¹≠Ar²) ligand

SUBMITTER: Takano H 

PROVIDER: S-EPMC9678890 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature