Depletion of CD206⁺ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.

ABSTRACT: Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Herein, we systemically investigated the communication between CD206⁺ M2-like macrophages and FAPs during the recovery process using a transgenic mouse model. Depletion of CD206⁺ M2-like macrophages or deletion of CD206⁺ M2-like macrophages-specific TGF-β1 gene induces myogenesis and muscle regeneration. We show that depletion of CD206⁺ M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of the FAP-specific foll

SUBMITTER: Nawaz A 

PROVIDER: S-EPMC9678897 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature