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Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.

ABSTRACT: The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional engagement of semantic memory system within the olfactory network, in an allele dosage-dependent manner. This suggests that the Met allele may promote adaptive neural reorganization to augment olfactory capacity.

SUBMITTER: Chao YT

PROVIDER: S-EPMC9678911 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.

Chao Yun-Ting YT Hong Tzu-Yi TY Yang Ching-Ju CJ Hsieh Jen-Chuen JC

Scientific reports 20221121 1

The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional ...[more]

PMID: 36411369

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