Decreased integration of default-mode network during a working memory task in schizophrenia with severe attention deficits.

ABSTRACT:

Background

Working memory (WM) and attention deficits are both important features of schizophrenia. WM is closely related to attention, for it acted as an important characteristic in activating and manipulating WM. However, the knowledge of neural mechanisms underlying the relationship between WM and attention deficits in schizophrenia is poorly investigated.

Methods

Graph theory was used to examine the network topology at the whole-brain and large-scale network levels among 125 schizophrenia patients with different severity of attention deficits (65 mild attention deficits; 46 moderate attention deficits; and 14 severe attention deficits) and 53 healthy controls (HCs) during an N-back WM task. These analyses were repeated in the same participants during the resting state.

SUBMITTER: Cheng P 

PROVIDER: S-EPMC9679280 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature