Gap Junction-Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells.

ABSTRACT: We have previously demonstrated that small molecular transfer, such as glucose, between hematopoietic stem cells (HSCs) or mesenchymal stem cells (MSCs) and vascular endothelial cells via gap junctions constitutes an important mechanism of stem cell therapy. Cell metabolites are high-potential small-molecule candidates that can be transferred to small molecules between stem cells and vascular endothelial cells. Here, we investigated the differences in metabolite levels between stem cells (HSCs and MSCs), vascular endothelial cells, and the levels of circulating non-hematopoietic white blood cells (WBCs). The results showed remarkable differences in metabolite concentrations between cells. Significantly higher concentrations of adenosine triphosphate (ATP), guanosine triphosphate (GTP), tot

SUBMITTER: Ogawa Y 

PROVIDER: S-EPMC9679345 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature