Myocardial interaction of apixaban after experimental acute volume overload.

ABSTRACT:

Objective

Acute volume overload (AVO) induces early ischemia-like changes in intramyocardial arteries. We investigated whether the Factor Xa (FXa) inhibitor apixaban interacts with the myocardium early after AVO.

Methods

Fifty-five syngeneic Fisher rats underwent surgical abdominal aortocaval fistula to induce AVO. Among them, 17 rats were treated with apixaban (10 mg/kg/day). The myocardial outcome was studied using histological analysis and by measuring atrial natriuretic peptide (ANP) and matrix metalloprotease 9 (MMP9) gene expression.

Results

After 3 days, the total number of intramyocardial arteries was significantly increased in the AVO+apixaban (AVO+A) group compared with that in the AVO group (12.0  ±  1.2 and 10.2 ± 1.5, point score units, respectivel

SUBMITTER: Huuskonen C 

PROVIDER: S-EPMC9679347 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature