Size of the protein-protein energy funnel in crowded environment.

ABSTRACT: Association of proteins to a significant extent is determined by their geometric complementarity. Large-scale recognition factors, which directly relate to the funnel-like intermolecular energy landscape, provide important insights into the basic rules of protein recognition. Previously, we showed that simple energy functions and coarse-grained models reveal major characteristics of the energy landscape. As new computational approaches increasingly address structural modeling of a whole cell at the molecular level, it becomes important to account for the crowded environment inside the cell. The crowded environment drastically changes protein recognition properties, and thus significantly alters the underlying energy landscape. In this study, we addressed the effect of crowding on the prote

SUBMITTER: Jenkins NW 

PROVIDER: S-EPMC9679368 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature