Mitochondrial RNA editing in Trypanoplasma borreli: New tools, new revelations.

ABSTRACT: The kinetoplastids are unicellular flagellates that derive their name from the 'kinetoplast', a region within their single mitochondrion harboring its organellar genome of high DNA content, called kinetoplast (k) DNA. Some protein products of this mitochondrial genome are encoded as cryptogenes; their transcripts require editing to generate an open reading frame. This happens through RNA editing, whereby small regulatory guide (g)RNAs direct the proper insertion and deletion of one or more uridines at each editing site within specific transcript regions. An accurate perspective of the kDNA expansion and evolution of their unique uridine insertion/deletion editing across kinetoplastids has been difficult to achieve. Here, we resolved the kDNA structure and editing patterns in the early-bran

SUBMITTER: Gerasimov ES 

PROVIDER: S-EPMC9679448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature