Markers of Kidney Function in Early Childhood and Association With Maternal Comorbidity.

ABSTRACT:

Importance

Kidney functional capacity is low at birth but doubles during the first 2 weeks of life and reaches near-adult levels at age 1 to 2 years. Existing reference intervals for markers of kidney function in newborns are mostly based on preterm newborns, newborns with illness, or small cohorts of term newborns, and the consequences of maternal comorbidities for newborn kidney function are sparsely described.

Objective

To establish robust reference intervals for creatinine and urea in healthy children in early childhood and to assess whether maternal comorbidity is associated with newborn creatinine and urea concentrations.

Design, setting, and participants

This multicenter, prospective, population-based cohort study assessed data and umbilical cord blood samples

SUBMITTER: Mohr Lytsen R 

PROVIDER: S-EPMC9679880 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature