A novel chemerin receptor 1 (Chemerin₁) takes part in the immune response of cobia (Rachycentron canadum).

ABSTRACT: Chemerin receptor 1 (Chemerin₁) plays a critical role in innate and adaptive immune systems. In this study, a cobia (Rachycentron canadum) Chemerin₁ was identified, and its molecular characterization and expression patterns were analyzed. Multiple sequence alignment revealed that the RcChemerin₁ possessed a typical dynein regulatory complex (DRC) motif. There was also a potential N-glycosylation site in the extracellular regions of the N-terminus and intracellular loops (ICL) 1 region. Phylogenetic analysis demonstrated that the RcChemerin₁ was clustered together with homologous proteins from other fish species. RcChemerin₁ was constitutively expressed in a wide range of tissues (especially in immune-related

SUBMITTER: Jiang B 

PROVIDER: S-EPMC9680076 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature