Differential production of prostaglandins and prostacyclins by liver and head kidney cells from Atlantic salmon challenged with arachidonic and eicosapentaenoic acids.

ABSTRACT: Polyunsaturated fatty acids such as arachidonic and eicosapentaenoic acids are the precursors of eicosanoid metabolites (e.g prostaglandins and prostacyclins) which regulate inflammatory and immune response processes in fish organs. The present research studies the differential production of PGI₂, PGI₃, PGE₂ and PGE₃ by primary liver and head kidney cells isolated from salmon and challenged with single or combined ARA and/or EPA. There was a significant increase in the production of PGE₂ and PGI₃ in both types of cells after exposure to single and combined fatty acids. Increased production of PGE₃ was only detected in liver cells after exposure to ARA+EPA. The levels of PGI₂ in liver cells were signific

SUBMITTER: Araujo P 

PROVIDER: S-EPMC9680099 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature