Impact of CHIKV Replication on the Global Proteome of Aedes albopictus Cells.

ABSTRACT: Arboviruses are some of the important causative agents of mosquito-mediated viral diseases. These viruses are transmitted between vector and host during the blood meal. Upon viral entry, host replication machinery is hijacked, supporting new virus particle production and thereby allowing viral survival in the host. In this process, host proteins interact with viral proteins to either facilitate viral replication, or they may provide antiviral defense mechanisms. In this study, we analyzed the impact of chikungunya virus (CHIKV) infection on the global proteome of Dicer active Aedes albopictus cells during the early and late time points of infection. We utilized a bottom-up approach of global proteomics analysis, and we used label-free quantitative mass spectrometry to identify the g

SUBMITTER: Kumar R 

PROVIDER: S-EPMC9680348 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature