Transcriptomic analysis of graft liver provides insight into the immune response of rat liver transplantation.

ABSTRACT:

Background

As an "immune-privileged organ", the liver has higher rates of both spontaneous tolerance and operational tolerance after being transplanted compared with other solid organs. Also, a large number of patients still need to take long-term immunosuppression regimens. Liver transplantation (LT) rejection involves varieties of pathophysiological processes and cell types, and a deeper understanding of LT immune response is urgently needed.

Methods

Homogenic and allogeneic rat LT models were established, and recipient tissue was collected on postoperative day 7. The degree of LT rejection was evaluated by liver pathological changes and liver function. Differentially expressed genes (DEGs) were detected by transcriptome sequencing and confirmed by reverse transcription-po

SUBMITTER: Cao W 

PROVIDER: S-EPMC9680555 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature