Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice.

ABSTRACT: Opioid misuse has dramatically increased over the last few decades resulting in many people suffering from opioid use disorder (OUD). The prevalence of opioid overdose has been driven by the development of new synthetic opioids, increased availability of prescription opioids, and more recently, the COVID-19 pandemic. Coinciding with increases in exposure to opioids, the United States has also observed increases in multiple Narcan (naloxone) administrations as life-saving measures for respiratory depression, and, thus, consequently, naloxone-precipitated withdrawal. Sleep dysregulation is a main symptom of OUD and opioid withdrawal syndrome, and therefore, should be a key facet of animal models of OUD. Here we examine the effect of precipitated and spontaneous morphine withdrawal on sleep b

SUBMITTER: Bedard ML 

PROVIDER: S-EPMC9681041 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature