A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection.

ABSTRACT: While the development of different vaccines has slowed the dissemination of SARS-CoV-2, the occurrence of breakthrough infections continues to fuel the pandemic. As a strategy to secure at least partial protection, with a single dose of a given COVID-19 vaccine to maximum possible fraction of the population, delayed administration of subsequent doses (or boosters) has been implemented in many countries. However, waning immunity and emergence of new variants of SARS-CoV-2 suggest that such measures may jeopardize the attainment of herd immunity due to intermittent lapses in protection. Optimizing vaccine dosing schedules could thus make the difference between periodic occurrence of breakthrough infections or effective control of the pandemic. To this end, we have developed a mechanis

SUBMITTER: Dogra P 

PROVIDER: S-EPMC9681049 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature