Association Between Atopic Dermatitis and Major Cardiovascular Outcomes: a Two-Sample Mendelian Randomization Study.

ABSTRACT:

Introduction

Atopic dermatitis (AD) has been linked to cardiovascular disease (CVD) in population-based studies, however, their causal relationship is still unclear.

Objectives

To evaluate the causal association of AD with risk of cardiovascular outcomes using a Mendelian randomization (MR) approach.

Methods

We extracted summary-level data for AD, stroke, heart failure, coronary artery disease (CAD), myocardial infarction, angina pectoris from published, nonoverlapping genome-wide association studies (GWAS). Inverse variance weighted (IVW) method was used as the primary analysis. Alternative methods, including weighted median, MR Egger, MR-Pleiotropy Residual Sum and Outlier, weighted mode, and leave-out analysis, were performed to examine potential pleiotropy.

Res

SUBMITTER: Qi H 

PROVIDER: S-EPMC9681179 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature