Age acquired skewed X chromosome inactivation is associated with adverse health outcomes in humans.

ABSTRACT:

Background

Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptionally silences either the maternal or paternal X in each cell of 46, XX females to balance the gene expression with 46, XY males. Age acquired XCI-skew describes the preferential selection of cells across a tissue resulting in an imbalance of XCI, which is particularly prevalent in blood tissues of ageing females, and yet its clinical consequences are unknown.

Methods

We assayed XCI in 1575 females from the TwinsUK population cohort using DNA extracted from whole blood. We employed prospective, cross-sectional, and intra-twin study d

SUBMITTER: Roberts AL 

PROVIDER: S-EPMC9681199 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature