Deriving causal relationships in resting-state functional connectivity using SSFO-based optogenetic fMRI.

ABSTRACT: Objective.The brain network has been extensively studied as a collection of brain regions that are functionally inter-connected. However, the study of the causal relationship in brain-wide functional connectivity, which is critical to the brain function, remains challenging. We aim to examine the feasibility of using (SSFO)-based optogenetic functional magnetic resonance imaging to infer the causal relationship (i.e. directional information) in the brain network.Approach.We combined SSFO-based optogenetics with fMRI in a resting-state rodent model to study how a local increase of excitability affects brain-wide neural activity and resting-state functional connectivity (RSFC). We incorporated Pearson's correlation and partial correlation analyses in a graphic model to derive t

SUBMITTER: Han X 

PROVIDER: S-EPMC9681600 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature