Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors.

ABSTRACT:

Objective

The purpose of this study is to report development of a malignant testicular germ cell tumor (GCT) in 2 young adult males with familial male-limited precocious puberty (FMPP) because of LHCGR pathogenic variants in 2 families. Secondarily, to study the possible relation between FMPP and testicular tumors and to investigate whether FMPP might predispose to development of malignant testicular tumors in adulthood a literature review is conducted.

Methods

Data on 6 cases in 2 families are obtained from the available medical records. In addition, a database search is performed in Cochrane, PubMed, and Embase for studies that report on a possible link between FMPP and testicular tumors.

Results

The characteristics of 6 males with FMPP based on activating LH recept

SUBMITTER: Kooij CD 

PROVIDER: S-EPMC9681611 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature