Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology.

ABSTRACT: While impaired fear generalization is known to underlie a wide range of psychopathology, the extent to which exposure to trauma by itself results in deficient fear generalization and its neural abnormalities is yet to be studied. Similarly, the neural function of intact fear generalization in people who endured trauma and did not develop significant psychopathology is yet to be characterized. Here, we utilize a generalization fMRI task, and a network connectivity approach to clarify putative behavioral and neural markers of trauma and resilience. The generalization task enables longitudinal assessments of threat discrimination learning. Trauma-exposed participants (TE; N = 62), compared to healthy controls (HC; N = 26), show lower activity reduction in salience network (SN) and right execu

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9681725 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature