Long-term use of antihypertensive medications, hypertension and colorectal cancer risk and mortality: a prospective cohort study.

ABSTRACT:

Background

Hypertension and the use of antihypertensive medications have been intensively investigated in relation to colorectal cancer (CRC). Prior epidemiologic studies have not been able to examine this topic with adequate confounding control and follow-up time, or disentangle the effects of antihypertensive agents and hypertension.

Methods

Eligible participants in the Nurses' Health Study and Health Professionals Follow-up Study were followed for up to 28 years, with repeat assessments of exposures. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals.

Results

In fully adjusted analyses based on both new-user and prevalent-user designs, there was no association between the use of beta-blockers, calcium-channel blockers,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9681847 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature