Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivors.

ABSTRACT:

Background

Non-seminoma testicular cancer survivors (TCS) have an increased risk of developing colorectal cancer (CRC) when they have been treated with platinum-based chemotherapy. Previously we demonstrated that among Hodgkin lymphoma survivors (HLS) there is enrichment of rare mismatch repair (MMR) deficient (MMRd) CRCs with somatic hits in MMR genes. We speculate that this phenomenon could also occur among other cancer survivors. We therefore aim to determine the MMR status and its underlying mechanism in CRC among TCS (TCS-CRC).

Methods

Thirty TCS-CRC, identified through the Dutch pathology registry, were analysed for MMR proteins by immunohistochemistry. Next-generation sequencing was performed in MMRd CRCs without MLH1 promoter hypermethylation (n = 4). Data were compa

SUBMITTER: Ykema BLM 

PROVIDER: S-EPMC9681876 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature