Dataset Information

Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study.

ABSTRACT: Subjects with subclinical respiratory dysfunction who do not meet the chronic obstructive pulmonary disease (COPD) criteria have attracted attention with regard to early COPD intervention. Our aim was to longitudinally investigate the risks for the development of airflow limitation (AFL) and dyspnoea, the main characteristics of COPD, in a large-scale community-based general population study. The Nagahama study included 9789 inhabitants, and a follow-up evaluation was conducted after 5 years. AFL was diagnosed using a fixed ratio (forced expiratory volume in one second (FEV₁)/forced vital capacity (FVC) < 0.7). We enrolled normal subjects aged 40-75 years with no AFL, dyspnoea or prior diagnosis of asthma or COPD at baseline. In total, 5865 subjects were analysed, 310 subjects had subclinical respiratory dysfunction (FEV₁/FVC < the lower limit of normal; n = 57, and FEV₁ < 80% of the predicted value (preserved ratio impaired spirometry); n = 256). A total of 5086 subjects attended the follow-up assessment, and 449 and 1021 subjects developed AFL and dyspnoea, respectively. Of these, 100 subjects developed AFL with dyspnoea. Baseline subclinical respiratory dysfunction was independently and significantly associated with AFL with dyspnoea development within 5 years. Subjects with subclinical respiratory dysfunction are at risk of developing COPD-like features and require careful monitoring.

SUBMITTER: Kogo M

PROVIDER: S-EPMC9681883 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study.

Kogo Mariko M Sato Susumu S Muro Shigeo S Matsumoto Hisako H Nomura Natsuko N Tashima Noriyuki N Oguma Tsuyoshi T Sunadome Hironobu H Nagasaki Tadao T Murase Kimihiko K Kawaguchi Takahisa T Tabara Yasuharu Y Matsuda Fumihiko F Chin Kazuo K Hirai Toyohiro T

Scientific reports 20221121 1

Subjects with subclinical respiratory dysfunction who do not meet the chronic obstructive pulmonary disease (COPD) criteria have attracted attention with regard to early COPD intervention. Our aim was to longitudinally investigate the risks for the development of airflow limitation (AFL) and dyspnoea, the main characteristics of COPD, in a large-scale community-based general population study. The Nagahama study included 9789 inhabitants, and a follow-up evaluation was conducted after 5 years. AF ...[more]

PMID: 36414653

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Dataset Information

Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study.

Publications

Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study.

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