The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression.

ABSTRACT: SALL2/Sall2 is a transcription factor associated with development, neuronal differentiation, and cancer. Interestingly, SALL2/Sall2 deficiency leads to failure of the optic fissure closure and neurite outgrowth, suggesting a positive role for SALL2/Sall2 in cell migration. However, in some cancer cells, SALL2 deficiency is associated with increased cell migration. To further investigate the role of Sall2 in the cell migration process, we used immortalized Sall2 knockout (Sall2 ^-/- ) and Sall2 wild-type (Sall2 ^+/+ ) mouse embryonic fibroblasts (iMEFs). Our results indicated that Sall2 positively regulates cell migration, promoting cell detachment and focal adhesions turnover. Sall2 deficiency decreased cell

SUBMITTER: Riffo E 

PROVIDER: S-EPMC9682130 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature