Chromomycin A₅ induces bona fide immunogenic cell death in melanoma.

ABSTRACT:

Purpose

Some first-line cytotoxic chemotherapics, e.g. doxorubicin, paclitaxel and oxaliplatin, induce activation of the immune system through immunogenic cell death (ICD). Tumor cells undergoing ICD function as a vaccine, releasing damage-associated molecular patterns (DAMPs), which act as adjuvants, and neoantigens of the tumor are recognized as antigens. ICD induction is rare, however it yields better and long-lasting antitumor responses to chemotherapy. Advanced metastatic melanoma (AMM) is incurable for more than half of patients. The discovery of ICD inducers against AMM is an interesting drug discovery strategy with high translational potential. Here we evaluated ICD induction of four highly cytotoxic chromomycins A (CA_5-8).

Methods

ICD features and

SUBMITTER: Florencio KGD 

PROVIDER: S-EPMC9682167 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature