A clinicopathologic and immunohistochemical study of primary and secondary breast angiosarcoma.

ABSTRACT:

Background

We aimed to study the clinicopathologic and immunohistochemical (IHC) (CD117, c-Myc, and p53) characteristics, and overall survival of primary and secondary breast angiosarcoma (BAS).

Methods

This was a retrospective study of BAS cases diagnosed between 1997 and 2020 at our institution. Hematoxylin and eosin-stained slides were reviewed for tumor morphology, margin status, and lymph node metastasis. CD117, p53, D2-40, CD31, and c-Myc IHC stains were performed on 11 viable tissue blocks. Additional clinical information was obtained from the electronic medical records.

Results

Seventeen patients with BAS were identified. Of these, five (29%) were primary and 12 (71%) were secondary BAS, respectively. The median age at diagnosis for primary BAS was 36 years. T

SUBMITTER: Abada E 

PROVIDER: S-EPMC9682221 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature