Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial.

ABSTRACT:

Importance

Chronic breathlessness is common in people with chronic obstructive pulmonary disease (COPD). Regular, low-dose, extended-release morphine may relieve breathlessness, but evidence about its efficacy and dosing is needed.

Objective

To determine the effect of different doses of extended-release morphine on worst breathlessness in people with COPD after 1 week of treatment.

Design, setting, and participants

Multicenter, double-blind, placebo-controlled randomized clinical trial including people with COPD and chronic breathlessness (defined as a modified Medical Research Council score of 3 to 4) conducted at 20 centers in Australia. People were enrolled between September 1, 2016, and November 20, 2019, and followed up through December 26, 2019.

Interventions

SUBMITTER: Ekstrom M 

PROVIDER: S-EPMC9682426 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature