Association of Benzodiazepine Treatment for Sleep Disorders With Drug Overdose Risk Among Young People.

ABSTRACT:

Importance

Benzodiazepines are prescribed for the treatment of adolescent sleep disorders; however, benzodiazepine overdoses occur, often in combination with opioids.

Objective

To evaluate whether benzodiazepine treatment for sleep disorders, compared with alternative pharmacologic treatments (trazodone, hydroxyzine, zolpidem, zaleplon, and eszopiclone), is associated with increased risk of drug overdose for young people.

Design, setting, and participants

This cohort study included privately insured people 10 to 29 years of age identified from a US commercial claims database (MarketScan), from January 1, 2009, to December 31, 2018. Young people with a sleep disorder diagnosis initiating benzodiazepine (n = 23 084) or comparator pharmacologic treatments (n = 66 706) we

SUBMITTER: Bushnell GA 

PROVIDER: S-EPMC9682430 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature