Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study.

ABSTRACT:

Background

Glucose metabolism has been reported to be affected by dietary patterns, while the underlying mechanisms involved remain unclear. This study aimed to investigate the potential mediation role of circulating metabolites in relation to dietary patterns for prediabetes and type 2 diabetes.

Methods

Data was derived from The Maastricht Study that comprised of 3441 participants (mean age of 60 years) with 28% type 2 diabetes patients by design. Dietary patterns were assessed using a validated food frequency questionnaire (FFQ), and the glucose metabolism status (GMS) was defined according to WHO guidelines. Both cross-sectional and prospective analyses were performed for the circulating metabolome to investigate their associations and mediations with responses to dietary

SUBMITTER: Yu EY 

PROVIDER: S-EPMC9682653 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature