White blood cells and chronic rhinosinusitis: a Mendelian randomization study.

ABSTRACT:

Background

Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely undetermined, which is likely due to the heterogeneity of the disease. White blood cell counts have been largely unexplored as a risk factor for CRS even though different types of white blood cells are involved in the inflammatory process of CRS.

Objective

To investigate causal associations between different types of white blood cells on risk of CRS utilizing a Mendelian randomization (MR) analysis.

Methods

A two-sample MR analysis was performed using respective GWAS summary statistics for the exposure traits (neutrophil count, eosinophil count, basophil count, lymphocyte count, and monocyte count) and outcome trait (CRS). For the exposure traits, the European Bioinformatics In

SUBMITTER: Pongdee T 

PROVIDER: S-EPMC9682667 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature