Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients.

ABSTRACT:

Background

Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha₂-adrenergic agonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesised that early sedation with dexmedetomidine as the primary agent would result in a reduced stress response compared to usual sedatives in critically ill ventilated adults.

Methods

This was a prospective sub-study nested within a multi-centre randomised controlled trial of early sedation with dexmedetomidine versus usual care. The primary outcome was the mean group differences in plasma levels of stress response biomarkers measured over 5 days following randomisation. Other hormonal, biological and physiological parameters were collected. Subgrou

SUBMITTER: Moore JPR 

PROVIDER: S-EPMC9682690 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature