Preoperative coagulation biomarkers associate with survival and pulmonary embolism after surgical treatment of non-spinal skeletal metastases.

ABSTRACT:

Background

Thrombotic complications are synergistic and associated with orthopedic procedures, trauma, and malignancy. Because cancer enhances coagulation activity and vice versa, we assessed preoperative biomarkers for survival and complications after treatment of pathologic fractures in non-spinal skeletal metastases.

Patients/methods

Our study population comprised 113 actual or impending pathologic fractures in 100 patients admitted to two referral centers. Laboratory variables were collected retrospectively from patient records and analyzed related to incidence of pulmonary embolism (PE) and mortality (Kaplan-Meier and Cox regression analyses and biomarker quartiles).

Results

Preoperative coagulation variables were high without exceptions. PE occurred in 12 patien

SUBMITTER: Matilainen S 

PROVIDER: S-EPMC9682700 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature