Lymphadenectomy in ovarian cancers: a meta-analysis of hazard ratios from randomized clinical trials.

ABSTRACT:

Background

The debate surrounding systematic lymphadenectomy in the epithelial cancers of the ovary (EOC) was temporarily put to rest by the LION trial. However, there was a glaring disparity between the number of patients registered and the number of patients randomized suggesting inadvertent selection. A subsequent meta-analysis after this trial included all types of studies in the literature (randomized, non-randomized, case series, and, retrospective cohort), thus diluting the results.

Methods

We conducted a meta-analysis of hazard ratios of randomized controlled trials, to study the role of systematic para-aortic and pelvic lymph node dissection in the EOC. A detailed search of MEDLINE, Cochrane, and Embase databases was done to look for the published randomized control

SUBMITTER: Purwar R 

PROVIDER: S-EPMC9682714 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature