Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies.

ABSTRACT:

Background

In recent decades, increasing longevity (among other factors) has fostered a rise in Parkinson's disease incidence. Although not exhaustively studied in this devastating disease, the impact of sex represents a critical variable in Parkinson's disease as epidemiological and clinical features differ between males and females.

Methods

To study sex bias in Parkinson's disease, we conducted a systematic review to select sex-labeled transcriptomic data from three relevant brain tissues: the frontal cortex, the striatum, and the substantia nigra. We performed differential expression analysis on each study chosen. Then we summarized the individual differential expression results with three tissue-specific meta-analyses and a global all-tissues meta-analysis. Finally, resu

SUBMITTER: Lopez-Cerdan A 

PROVIDER: S-EPMC9682715 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature