CD6-mediated inhibition of T cell activation via modulation of Ras.

ABSTRACT:

Background

CD6 is one of many cell surface receptors known to regulate signal transduction upon T cell activation. However, whether CD6 mediates costimulatory or inhibitory signals is controversial. When T cells engage with antigen presenting cells (APCs), CD6 interacts with its ligand CD166 at the cell-cell interface while the cytosolic tail assembles a complex signalosome composed of adaptors and effector enzymes, that may either trigger activating signaling cascades, or instead modulate the intensity of signaling. Except for a few cytosolic adaptors that connect different components of the CD6 signalosome, very little is known about the mechanistic effects of the cytosolic effectors that bind CD6.

Methods

Jurkat model T cells were transfected to express wild-type (WT) CD6

SUBMITTER: Henriques SN 

PROVIDER: S-EPMC9682754 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature