Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis.

ABSTRACT:

Background

Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endometriosis treatments have low efficacy and cause adverse effects in endometriosis patients. Consequently, alternative endometriosis treatments targeting endometriosis-specific factors are in demand. In this context, ERβ was selected as a druggable target for endometriosis due to its critical role in progression. Therefore, selective targeting of ERβ without inhibiting ERα activity would be a new paradigm for endometriosis treatment to overcome the low efficacy and adverse effects of hormonal endometriosis therapy.

Methods

Cell-based ERβ and ERα activity assay

SUBMITTER: Park Y 

PROVIDER: S-EPMC9682776 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature