Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis.

ABSTRACT: Obesity is a global pandemic that is causally linked to many life-threatening diseases. Apart from some rare genetic conditions, the biological drivers of overeating and reduced activity are unclear. Here, we show that neurotensin-expressing neurons in the mouse interstitial nucleus of the posterior limb of the anterior commissure (IPAC), a nucleus of the central extended amygdala, encode dietary preference for unhealthy energy-dense foods. Optogenetic activation of IPAC^Nts neurons promotes obesogenic behaviors, such as hedonic eating, and modulates food preference. Conversely, acute inhibition of IPAC^Nts neurons reduces feeding and decreases hedonic eating. Chronic inactivation of IPAC^Nts neurons recapitulates these effects, reduces preference for sweet, n

SUBMITTER: Furlan A 

PROVIDER: S-EPMC9682790 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature