Transmissible Gastroenteritis Virus Nucleocapsid Protein Interacts with Na⁺/H⁺ Exchanger 3 To Reduce Na⁺/H⁺ Exchanger Activity and Promote Piglet Diarrhea.

ABSTRACT: Transmissible gastroenteritis virus (TGEV) is member of the family Coronaviridae and mainly causes acute diarrhea. TGEV infection is characterized by vomiting, watery diarrhea, and severe dehydration, resulting in high mortality rates in neonatal piglets. TGEV infection symptoms are related to an imbalance of sodium absorption in small intestinal epithelial cells; however, the etiology of sodium imbalance diarrhea caused by TGEV remains unclear. In this study, we performed transcriptomic analysis of intestinal tissues from infected and healthy piglets and observed that the expression of NHE3, encoding Na⁺/H⁺ exchanger 3 (NHE3), the main exchanger of electroneutral sodium in intestinal epithelial cells, was significantly reduced upon TGEV infection. We al

SUBMITTER: Niu Z 

PROVIDER: S-EPMC9682987 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature